Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 20 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin improves rheumatoid arthritis symptoms
We conducted a clinical trial to explore how curcumin, a compound found in turmeric, affects women with rheumatoid arthritis (RA). Over the course of eight weeks, 48 participants took either a daily curcumin capsule or a placebo. This double-blind, placebo-controlled design ensured that neither the participants nor the researchers knew who was receiving the actual treatment, which adds credibility to our findings.
At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).
While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.
At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).
While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.
Read More
9
Turmeric reduces inflammation in lupus
We conducted a study to see how turmeric, specifically its active compound curcumin, affects autoimmune disorders, particularly systemic lupus erythematosus (SLE). Our group involved 70 patients aged 18 to 60, participating in a well-structured, randomized, triple-blinded trial over ten weeks.
Participants were divided into two groups. One group received 1000 mg of curcumin daily, while the other received a placebo. Throughout the study, we closely monitored various inflammatory markers in the patients' blood, such as anti-double stranded DNA (anti-ds DNA) and interleukin-6 (IL-6), both known for their roles in inflammation and autoimmune activity.
At the end of the trial, we observed notable improvements in the curcumin group. Specifically, levels of anti-ds DNA and IL-6 dropped significantly compared to their baseline measurements. This suggests that curcumin could be a beneficial supplement for reducing certain inflammatory markers in SLE patients.
However, it's important to note that while curcumin showed promise, no significant changes were observed in other inflammatory markers assessed during the study. Thus, while we can advocate for curcumin as a potentially effective adjuvant therapy, further research is necessary to fully understand its impact on SLE and other autoimmune conditions.
Participants were divided into two groups. One group received 1000 mg of curcumin daily, while the other received a placebo. Throughout the study, we closely monitored various inflammatory markers in the patients' blood, such as anti-double stranded DNA (anti-ds DNA) and interleukin-6 (IL-6), both known for their roles in inflammation and autoimmune activity.
At the end of the trial, we observed notable improvements in the curcumin group. Specifically, levels of anti-ds DNA and IL-6 dropped significantly compared to their baseline measurements. This suggests that curcumin could be a beneficial supplement for reducing certain inflammatory markers in SLE patients.
However, it's important to note that while curcumin showed promise, no significant changes were observed in other inflammatory markers assessed during the study. Thus, while we can advocate for curcumin as a potentially effective adjuvant therapy, further research is necessary to fully understand its impact on SLE and other autoimmune conditions.
Read More
9
We explored the impact of curcumin, a compound found in turmeric, on lupus nephritis, an autoimmune disorder that can severely affect kidney function. In our research, we utilized two mouse models of lupus to observe how curcumin might help regulate inflammation and neutrophil migration—key players in the inflammatory process.
By administering curcumin at a dose of 50 mg/kg through intraperitoneal injections, we closely monitored the kidneys of the mice. We used various techniques, including histological staining and protein analysis, to assess how curcumin influenced histopathological changes and inflammatory factors.
Our findings show that curcumin significantly lessens the inflammation associated with lupus nephritis. It effectively reduced the recruitment of neutrophils and the release of pro-inflammatory substances in the kidneys. Mechanistically, curcumin appears to act by inhibiting the PI3K/AKT/NF-κB signaling pathway, which is pivotal in promoting neutrophil migration and subsequent renal inflammation.
Overall, this study highlights curcumin's potential as a therapeutic target for managing lupus nephritis, offering hope for new treatment strategies against this complex autoimmune disorder.
By administering curcumin at a dose of 50 mg/kg through intraperitoneal injections, we closely monitored the kidneys of the mice. We used various techniques, including histological staining and protein analysis, to assess how curcumin influenced histopathological changes and inflammatory factors.
Our findings show that curcumin significantly lessens the inflammation associated with lupus nephritis. It effectively reduced the recruitment of neutrophils and the release of pro-inflammatory substances in the kidneys. Mechanistically, curcumin appears to act by inhibiting the PI3K/AKT/NF-κB signaling pathway, which is pivotal in promoting neutrophil migration and subsequent renal inflammation.
Overall, this study highlights curcumin's potential as a therapeutic target for managing lupus nephritis, offering hope for new treatment strategies against this complex autoimmune disorder.
Read More
Most Useful Reviews
8
Normalised bowel function
32 people found this helpful
I highly recommend curcumin for managing my autoimmune disorder, Crohn's disease. After over 10 years of battling bowel problems and trying various ineffective medications, I discovered curcumin online. Its natural composition and anti-inflammatory properties caught my attention. Within two weeks, my stool returned to normal, and my overall condition improved. Following a strict diet is crucial for those with Crohn's. Wishing everyone good health!
Read More
9
Significant liver improvement
28 people found this helpful
After my husband suffered severe liver damage post-COVID, we tried SAMe and this particular curcumin for three weeks. The results were outstanding, with remarkable test improvements. We chose this curcumin for its superior absorption, as recommended by our nutritionist. We'll continue taking it for maintenance and overall health. Happy to share this useful information!
Read More
9
Anti-cancer action
23 people found this helpful
Curcumin is believed to possess powerful anti-cancer properties and is a strong antioxidant. I prefer Dr's Best 1000 mg caplets due to affordability and take it twice daily.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
We explored the effectiveness of curcumin, a well-known compound from turmeric, in combatting autoimmune uveitis, a serious eye condition that can lead to blindness. The focus of our investigation was on a novel formulation of curcumin mixed with hyaluronic acid to create nanoparticles. This combination aimed to enhance the absorption and effectiveness of curcumin, making it a potential game-changer in treating inflammatory disorders like uveitis.
Through comprehensive studies both in lab settings and on living organisms, we observed that these curcumin nanoparticles showed impressive antioxidant properties. They mimicked natural antioxidant enzymes and demonstrated the ability to scavenge harmful free radicals in the body. Our findings suggested that these nanoparticles not only reduced oxidative stress but also alleviated inflammation, leading to improved health outcomes in retinal tissues.
Importantly, the nanoparticles worked by specifically targeting certain cells, which allowed them to trigger protective pathways within the body. This pathway, known as the Keap1/Nrf2/HO-1 signaling, is crucial for handling oxidative damage. While curcumin itself has potential benefits, its conventional use has limitations due to poor absorption; our formulation appears to address these concerns effectively.
Overall, our study highlights the promise of turmeric-derived curcumin in the fight against autoimmune disorders, especially when enhanced through innovative nanoparticle technology. This advancement could offer a significant improvement over current treatment options.
Through comprehensive studies both in lab settings and on living organisms, we observed that these curcumin nanoparticles showed impressive antioxidant properties. They mimicked natural antioxidant enzymes and demonstrated the ability to scavenge harmful free radicals in the body. Our findings suggested that these nanoparticles not only reduced oxidative stress but also alleviated inflammation, leading to improved health outcomes in retinal tissues.
Importantly, the nanoparticles worked by specifically targeting certain cells, which allowed them to trigger protective pathways within the body. This pathway, known as the Keap1/Nrf2/HO-1 signaling, is crucial for handling oxidative damage. While curcumin itself has potential benefits, its conventional use has limitations due to poor absorption; our formulation appears to address these concerns effectively.
Overall, our study highlights the promise of turmeric-derived curcumin in the fight against autoimmune disorders, especially when enhanced through innovative nanoparticle technology. This advancement could offer a significant improvement over current treatment options.
Read More
9
Turmeric reduces inflammation in lupus
We conducted a study to see how turmeric, specifically its active compound curcumin, affects autoimmune disorders, particularly systemic lupus erythematosus (SLE). Our group involved 70 patients aged 18 to 60, participating in a well-structured, randomized, triple-blinded trial over ten weeks.
Participants were divided into two groups. One group received 1000 mg of curcumin daily, while the other received a placebo. Throughout the study, we closely monitored various inflammatory markers in the patients' blood, such as anti-double stranded DNA (anti-ds DNA) and interleukin-6 (IL-6), both known for their roles in inflammation and autoimmune activity.
At the end of the trial, we observed notable improvements in the curcumin group. Specifically, levels of anti-ds DNA and IL-6 dropped significantly compared to their baseline measurements. This suggests that curcumin could be a beneficial supplement for reducing certain inflammatory markers in SLE patients.
However, it's important to note that while curcumin showed promise, no significant changes were observed in other inflammatory markers assessed during the study. Thus, while we can advocate for curcumin as a potentially effective adjuvant therapy, further research is necessary to fully understand its impact on SLE and other autoimmune conditions.
Participants were divided into two groups. One group received 1000 mg of curcumin daily, while the other received a placebo. Throughout the study, we closely monitored various inflammatory markers in the patients' blood, such as anti-double stranded DNA (anti-ds DNA) and interleukin-6 (IL-6), both known for their roles in inflammation and autoimmune activity.
At the end of the trial, we observed notable improvements in the curcumin group. Specifically, levels of anti-ds DNA and IL-6 dropped significantly compared to their baseline measurements. This suggests that curcumin could be a beneficial supplement for reducing certain inflammatory markers in SLE patients.
However, it's important to note that while curcumin showed promise, no significant changes were observed in other inflammatory markers assessed during the study. Thus, while we can advocate for curcumin as a potentially effective adjuvant therapy, further research is necessary to fully understand its impact on SLE and other autoimmune conditions.
Read More
9
Curcumin helps manage rheumatoid arthritis
We investigated how turmeric, in the form of curcumin (CUR), alongside triptolide (TPL), affects rheumatoid arthritis (RA), a chronic autoimmune condition. By examining a model of collagen-induced arthritis in rats, we aimed to uncover the potential benefits that these compounds might offer in terms of reducing symptoms and promoting better health outcomes for patients with RA.
Our findings revealed that the combination of TPL and CUR helped diminish the severity of RA in these rats while also lowering the levels of certain inflammatory markers found in their blood. These markers included rheumatoid factor and various cytokines linked to inflammation, such as IL-17 and TNF-α. The treatment appeared to improve cell growth and promote necessary apoptosis, or cell death, in a controlled way, which is vital in managing RA.
Importantly, we noted that TPL and CUR worked together to inhibit the IL-17/NF-κB signaling pathway, which plays a significant role in inflammatory responses within the body. This inhibition may be crucial for individuals suffering from autoimmune conditions like RA, as it could lead to a reduction in inflammation and more effective management of the disease.
While our study puts a spotlight on the combined effects of TPL and CUR, it also emphasizes that understanding turmeric's standalone impact specifically requires further investigation.
Our findings revealed that the combination of TPL and CUR helped diminish the severity of RA in these rats while also lowering the levels of certain inflammatory markers found in their blood. These markers included rheumatoid factor and various cytokines linked to inflammation, such as IL-17 and TNF-α. The treatment appeared to improve cell growth and promote necessary apoptosis, or cell death, in a controlled way, which is vital in managing RA.
Importantly, we noted that TPL and CUR worked together to inhibit the IL-17/NF-κB signaling pathway, which plays a significant role in inflammatory responses within the body. This inhibition may be crucial for individuals suffering from autoimmune conditions like RA, as it could lead to a reduction in inflammation and more effective management of the disease.
While our study puts a spotlight on the combined effects of TPL and CUR, it also emphasizes that understanding turmeric's standalone impact specifically requires further investigation.
Read More
9
Our investigation focused on how a specific microRNA, known as Clo-miR-14, derived from the turmeric plant, Curcuma longa, can impact autoimmune disorders like rheumatoid arthritis (RA). We examined this miRNA's potential benefits, including its ability to withstand high temperatures and be absorbed in the body when taken through our regular diet.
We conducted both in vitro and in vivo studies to see how Clo-miR-14 might alleviate symptoms similar to those of RA. Our findings were encouraging: this plant-based miRNA exhibited excellent thermal stability, even at 100°C, and significantly lowered levels of pro-inflammatory cytokines like TNF, IL-1β, and IL-6. This suggests that incorporating turmeric into our diets could provide a novel approach in managing inflammatory conditions like RA.
Overall, it appears that Clo-miR-14 can be a potent candidate for RNA-based therapies aimed at treating rheumatoid arthritis, showcasing the medicinal potential that plant-derived microRNAs hold for autoimmune disorders.
We conducted both in vitro and in vivo studies to see how Clo-miR-14 might alleviate symptoms similar to those of RA. Our findings were encouraging: this plant-based miRNA exhibited excellent thermal stability, even at 100°C, and significantly lowered levels of pro-inflammatory cytokines like TNF, IL-1β, and IL-6. This suggests that incorporating turmeric into our diets could provide a novel approach in managing inflammatory conditions like RA.
Overall, it appears that Clo-miR-14 can be a potent candidate for RNA-based therapies aimed at treating rheumatoid arthritis, showcasing the medicinal potential that plant-derived microRNAs hold for autoimmune disorders.
Read More
9
We explored the impact of curcumin, a compound found in turmeric, on lupus nephritis, an autoimmune disorder that can severely affect kidney function. In our research, we utilized two mouse models of lupus to observe how curcumin might help regulate inflammation and neutrophil migration—key players in the inflammatory process.
By administering curcumin at a dose of 50 mg/kg through intraperitoneal injections, we closely monitored the kidneys of the mice. We used various techniques, including histological staining and protein analysis, to assess how curcumin influenced histopathological changes and inflammatory factors.
Our findings show that curcumin significantly lessens the inflammation associated with lupus nephritis. It effectively reduced the recruitment of neutrophils and the release of pro-inflammatory substances in the kidneys. Mechanistically, curcumin appears to act by inhibiting the PI3K/AKT/NF-κB signaling pathway, which is pivotal in promoting neutrophil migration and subsequent renal inflammation.
Overall, this study highlights curcumin's potential as a therapeutic target for managing lupus nephritis, offering hope for new treatment strategies against this complex autoimmune disorder.
By administering curcumin at a dose of 50 mg/kg through intraperitoneal injections, we closely monitored the kidneys of the mice. We used various techniques, including histological staining and protein analysis, to assess how curcumin influenced histopathological changes and inflammatory factors.
Our findings show that curcumin significantly lessens the inflammation associated with lupus nephritis. It effectively reduced the recruitment of neutrophils and the release of pro-inflammatory substances in the kidneys. Mechanistically, curcumin appears to act by inhibiting the PI3K/AKT/NF-κB signaling pathway, which is pivotal in promoting neutrophil migration and subsequent renal inflammation.
Overall, this study highlights curcumin's potential as a therapeutic target for managing lupus nephritis, offering hope for new treatment strategies against this complex autoimmune disorder.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Normalised bowel function
32 people found this helpful
I highly recommend curcumin for managing my autoimmune disorder, Crohn's disease. After over 10 years of battling bowel problems and trying various ineffective medications, I discovered curcumin online. Its natural composition and anti-inflammatory properties caught my attention. Within two weeks, my stool returned to normal, and my overall condition improved. Following a strict diet is crucial for those with Crohn's. Wishing everyone good health!
Read More
9
Significant liver improvement
28 people found this helpful
After my husband suffered severe liver damage post-COVID, we tried SAMe and this particular curcumin for three weeks. The results were outstanding, with remarkable test improvements. We chose this curcumin for its superior absorption, as recommended by our nutritionist. We'll continue taking it for maintenance and overall health. Happy to share this useful information!
Read More
9
Anti-cancer action
23 people found this helpful
Curcumin is believed to possess powerful anti-cancer properties and is a strong antioxidant. I prefer Dr's Best 1000 mg caplets due to affordability and take it twice daily.
Read More
9
Decreased inflammation
11 people found this helpful
This is my second order of curcumin, which has significantly reduced inflammation in my husband’s autoimmune disorder, IBD. His calprotectin levels dropped from 480 to 180, while following the AIP diet and taking zinc. Overall, these measures together have effectively decreased inflammation, as evidenced by the reduction in his C-reactive protein from 3 to 0.
Read More
9
Joint health support
4 people found this helpful
I have been using curcumin, known for its anti-inflammatory properties, for some time, and I am thoroughly pleased. It supports joint health and benefits my digestive system. I’ve been ordering it for a long time and recommend it to others!
Read More
Frequently Asked Questions
8
Normalised bowel function
32 people found this helpful
I highly recommend curcumin for managing my autoimmune disorder, Crohn's disease. After over 10 years of battling bowel problems and trying various ineffective medications, I discovered curcumin online. Its natural composition and anti-inflammatory properties caught my attention. Within two weeks, my stool returned to normal, and my overall condition improved. Following a strict diet is crucial for those with Crohn's. Wishing everyone good health!
9
Significant liver improvement
28 people found this helpful
After my husband suffered severe liver damage post-COVID, we tried SAMe and this particular curcumin for three weeks. The results were outstanding, with remarkable test improvements. We chose this curcumin for its superior absorption, as recommended by our nutritionist. We'll continue taking it for maintenance and overall health. Happy to share this useful information!
7.5
Pain reduction
4 people found this helpful
Curcumin helped reduce my rheumatoid arthritis pain significantly. To enhance its effectiveness, I recommend taking it with piperine, as the results are immediate. Limit intake to two capsules a day. I experienced diarrhoea after exceeding that, but overall, I recommend this product!
9
Decreased inflammation
11 people found this helpful
This is my second order of curcumin, which has significantly reduced inflammation in my husband’s autoimmune disorder, IBD. His calprotectin levels dropped from 480 to 180, while following the AIP diet and taking zinc. Overall, these measures together have effectively decreased inflammation, as evidenced by the reduction in his C-reactive protein from 3 to 0.
7.5
Improved joint pain
3 people found this helpful
I have been taking curcumin for joint pain for two weeks, and I've already noticed improvement! At 29 years old, I switched from NSAIDs to dietary supplements, specifically curcumin and boswellia, taking one tablet daily. The NSAIDs relieved inflammation, but the supplements have been even more effective; my remaining pain has vanished quickly. The tablets are easy to swallow and tasteless, making them a great choice.
7.5
Improved digestion
1 people found this helpful
I've been using probiotics for a number of years for my leaky gut and digestive issues. A friend introduced me to spore-biotics, and I decided to try Youtheory as they were more affordable. I take one pill per day alongside regular probiotics. A few months later, I noticed improvements in my digestion and more regular bowel movements. It's surprising to find something new and relatively inexpensive that seems to work after trying numerous remedies for my autoimmune disorder.
7.5
Safe hangover remedy
1 people found this helpful
This supplement is safe to take! I bought it for my husband's hangovers. I combine it with curcumin, B vitamins, and NAC, and I feel great the next day. It seems beneficial for autoimmune disorders and has anti-inflammatory effects.
9
Turmeric reduces inflammation in lupus
We conducted a study to see how turmeric, specifically its active compound curcumin, affects autoimmune disorders, particularly systemic lupus erythematosus (SLE). Our group involved 70 patients aged 18 to 60, participating in a well-structured, randomized, triple-blinded trial over ten weeks.
Participants were divided into two groups. One group received 1000 mg of curcumin daily, while the other received a placebo. Throughout the study, we closely monitored various inflammatory markers in the patients' blood, such as anti-double stranded DNA (anti-ds DNA) and interleukin-6 (IL-6), both known for their roles in inflammation and autoimmune activity.
At the end of the trial, we observed notable improvements in the curcumin group. Specifically, levels of anti-ds DNA and IL-6 dropped significantly compared to their baseline measurements. This suggests that curcumin could be a beneficial supplement for reducing certain inflammatory markers in SLE patients.
However, it's important to note that while curcumin showed promise, no significant changes were observed in other inflammatory markers assessed during the study. Thus, while we can advocate for curcumin as a potentially effective adjuvant therapy, further research is necessary to fully understand its impact on SLE and other autoimmune conditions.
Participants were divided into two groups. One group received 1000 mg of curcumin daily, while the other received a placebo. Throughout the study, we closely monitored various inflammatory markers in the patients' blood, such as anti-double stranded DNA (anti-ds DNA) and interleukin-6 (IL-6), both known for their roles in inflammation and autoimmune activity.
At the end of the trial, we observed notable improvements in the curcumin group. Specifically, levels of anti-ds DNA and IL-6 dropped significantly compared to their baseline measurements. This suggests that curcumin could be a beneficial supplement for reducing certain inflammatory markers in SLE patients.
However, it's important to note that while curcumin showed promise, no significant changes were observed in other inflammatory markers assessed during the study. Thus, while we can advocate for curcumin as a potentially effective adjuvant therapy, further research is necessary to fully understand its impact on SLE and other autoimmune conditions.
9
Curcumin helps manage rheumatoid arthritis
We investigated how turmeric, in the form of curcumin (CUR), alongside triptolide (TPL), affects rheumatoid arthritis (RA), a chronic autoimmune condition. By examining a model of collagen-induced arthritis in rats, we aimed to uncover the potential benefits that these compounds might offer in terms of reducing symptoms and promoting better health outcomes for patients with RA.
Our findings revealed that the combination of TPL and CUR helped diminish the severity of RA in these rats while also lowering the levels of certain inflammatory markers found in their blood. These markers included rheumatoid factor and various cytokines linked to inflammation, such as IL-17 and TNF-α. The treatment appeared to improve cell growth and promote necessary apoptosis, or cell death, in a controlled way, which is vital in managing RA.
Importantly, we noted that TPL and CUR worked together to inhibit the IL-17/NF-κB signaling pathway, which plays a significant role in inflammatory responses within the body. This inhibition may be crucial for individuals suffering from autoimmune conditions like RA, as it could lead to a reduction in inflammation and more effective management of the disease.
While our study puts a spotlight on the combined effects of TPL and CUR, it also emphasizes that understanding turmeric's standalone impact specifically requires further investigation.
Our findings revealed that the combination of TPL and CUR helped diminish the severity of RA in these rats while also lowering the levels of certain inflammatory markers found in their blood. These markers included rheumatoid factor and various cytokines linked to inflammation, such as IL-17 and TNF-α. The treatment appeared to improve cell growth and promote necessary apoptosis, or cell death, in a controlled way, which is vital in managing RA.
Importantly, we noted that TPL and CUR worked together to inhibit the IL-17/NF-κB signaling pathway, which plays a significant role in inflammatory responses within the body. This inhibition may be crucial for individuals suffering from autoimmune conditions like RA, as it could lead to a reduction in inflammation and more effective management of the disease.
While our study puts a spotlight on the combined effects of TPL and CUR, it also emphasizes that understanding turmeric's standalone impact specifically requires further investigation.
9
We explored the impact of curcumin, a compound found in turmeric, on lupus nephritis, an autoimmune disorder that can severely affect kidney function. In our research, we utilized two mouse models of lupus to observe how curcumin might help regulate inflammation and neutrophil migration—key players in the inflammatory process.
By administering curcumin at a dose of 50 mg/kg through intraperitoneal injections, we closely monitored the kidneys of the mice. We used various techniques, including histological staining and protein analysis, to assess how curcumin influenced histopathological changes and inflammatory factors.
Our findings show that curcumin significantly lessens the inflammation associated with lupus nephritis. It effectively reduced the recruitment of neutrophils and the release of pro-inflammatory substances in the kidneys. Mechanistically, curcumin appears to act by inhibiting the PI3K/AKT/NF-κB signaling pathway, which is pivotal in promoting neutrophil migration and subsequent renal inflammation.
Overall, this study highlights curcumin's potential as a therapeutic target for managing lupus nephritis, offering hope for new treatment strategies against this complex autoimmune disorder.
By administering curcumin at a dose of 50 mg/kg through intraperitoneal injections, we closely monitored the kidneys of the mice. We used various techniques, including histological staining and protein analysis, to assess how curcumin influenced histopathological changes and inflammatory factors.
Our findings show that curcumin significantly lessens the inflammation associated with lupus nephritis. It effectively reduced the recruitment of neutrophils and the release of pro-inflammatory substances in the kidneys. Mechanistically, curcumin appears to act by inhibiting the PI3K/AKT/NF-κB signaling pathway, which is pivotal in promoting neutrophil migration and subsequent renal inflammation.
Overall, this study highlights curcumin's potential as a therapeutic target for managing lupus nephritis, offering hope for new treatment strategies against this complex autoimmune disorder.
References
- Tang W, Huang X, Yi YD, Cao F, Deng M, et al. Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway. J Nanobiotechnology. 2025;23:89. 10.1186/s12951-024-03082-3
- Sedighi S, Faramarzipalangar Z, Mohammadi E, Aghamohammadi V, Bahnemiri MG, et al. The effects of curcumin supplementation on inflammatory markers in systemic lupus erythematosus patients: a randomized placebo-controlled trial. Eur J Nutr. 2024;64:8. 10.1007/s00394-024-03515-7
- Nosratabadi R, Ranjkesh M, Safari M, Ramezani M, Zainodini N, et al. Effects of Curcumin in Free and Phytosomal Forms on the Expression of T Helper1 and Regulatory T Cells' Transcription Factors in Collagen-Induced Arthritis. Adv Biomed Res. 2024;13:69. 10.4103/abr.abr_291_23
- Zhang C, Weng Y, Wang H, Zhan S, Li C, et al. A synergistic effect of triptolide and curcumin on rheumatoid arthritis by improving cell proliferation and inducing cell apoptosis via inhibition of the IL-17/NF-κB signaling pathway. Int Immunopharmacol. 2024;142:112953. 10.1016/j.intimp.2024.112953
- Sarkar A, Saquib M, Chakraborty D, Mann S, Malik S, et al. Clo-miR-14: a medicinally valued spice-derived miRNA with therapeutic implications in rheumatoid arthritis. Biosci Rep. 2024;44. 10.1042/BSR20240311
- Yang H, Zhang H, Tian L, Guo P, Liu S, et al. Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway. Lupus Sci Med. 2024;11. 10.1136/lupus-2024-001220
- El-Gabalawy H. The Impact of Rheumatoid Arthritis on First Nations and How We Can Work With Communities to Prevent It. J Rheumatol. 2024;51:3. 10.3899/jrheum.2024-0369_dunlop-dottridge
- Cao F, Liang K, Tang WW, Ni QY, Ji ZY, et al. Polyvinylpyrrolidone-curcumin nanoparticles with immune regulatory and metabolism regulatory effects for the treatment of experimental autoimmune uveitis. J Control Release. 2024;372:551. 10.1016/j.jconrel.2024.06.047
- Koohpeyma F, Khodaparast Z, Salehi S, Danesh S, Gheshlagh FM, et al. The ameliorative effects of curcumin nanomicelle on testicular damage in the mouse model of multiple sclerosis. BMC Complement Med Ther. 2024;24:200. 10.1186/s12906-024-04423-3
- Sun J, Du J, Liu X, An J, Hu Y, et al. Chondroitin sulfate-modified tragacanth gum-gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis. J Nanobiotechnology. 2024;22:270. 10.1186/s12951-024-02540-2
- Pourhabibi-Zarandi F, Rafraf M, Zayeni H, Asghari-Jafarabadi M, Ebrahimi AA. The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2024;38:3552. 10.1002/ptr.8225
- Fasihi M, Samimi-Badabi M, Robat-Jazi B, Bitarafan S, Moghadasi AN, et al. Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients. Antiinflamm Antiallergy Agents Med Chem. 2024;23:138. 10.2174/0118715230293847240314073359
- Lu B, Zhong Y, Zhang J, Zhang J. Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model. ACS Appl Mater Interfaces. 2024;16:17080. 10.1021/acsami.3c17091
- Deng T, Xu J, Wang Q, Wang X, Jiao Y, et al. Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis. Front Pharmacol. 2024;15:1369337. 10.3389/fphar.2024.1369337
- Khosropour S, Shahvarooghi E, Rezaeizadeh H, Esmaeelzadeh M. Curcumin and Its Semisynthetic Derivative F-Curcumin Ameliorate the Expression of Cytokines in Autoimmune Encephalomyelitis Mouse Models of Multiple Sclerosis. Iran J Allergy Asthma Immunol. 2023;22:575. 10.18502/ijaai.v22i6.14646
- Wahono CS, Susianti H, Hakim AL, Rosita F, Pratama MZ, et al. Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients. Curr Rheumatol Rev. 2024;20:586. 10.2174/0115733971276106231226071002
